A Comprehensive Review on Weight Gain following Discontinuation of Glucagon-Like Peptide-1 Receptor Agonists for Obesity (2024)

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A Comprehensive Review on Weight Gain following Discontinuation of Glucagon-Like Peptide-1 Receptor Agonists for Obesity (2024)

FAQs

Will I gain weight after stopping GLP-1? ›

Patients commonly regain weight after they stop taking GLP-1 medications, and a new, albeit small, survey indicates that patients who ceased anti-obesity medication reported consuming more calories. GLP-1 drugs change a person's biochemistry, making them feel fuller longer and slowing digestion.

Do GLP-1 agonists help with weight loss? ›

Studies have found that all GLP-1 drugs can lead to weight loss of about 10.5 to 15.8 pounds (4.8 to 7.2 kilograms, or kg) when using liraglutide.

Can glucagon like peptide 1 GLP-1 help you lose weight? ›

GLP-1 agonists are medications that help lower blood sugar levels and promote weight loss. There are many different types. And they're just one part of your treatment plan if you have Type 2 diabetes or obesity. Your healthcare provider can help you decide if they're right for you.

What GLP-1 drugs are approved for weight loss? ›

Quick list of GLP-1 drugs
Brand name (generic name)List price*Approved use
Zepbound (tirzepatide)$1,060.00weight loss
Saxenda (liraglutide)$1,349.02weight loss
Victoza (liraglutide)$543.51 or $815.27 (depending on dose)type 2 diabetes
Trulicity (dulaglutide)$977.42type 2 diabetes
6 more rows
May 20, 2024

What happens after you stop taking GLP-1? ›

The doses of GLP-1 provided by semaglutide and tirzepatide are far greater than the body would naturally expect to receive, he says, which may suppress the body's ability to secrete GLP-1 on its own. As a result, people's hunger may return even more voraciously when they cease their doses, he explains.

Is there sustained weight loss after discontinuation of GLP-1 agonist for obesity treatment? ›

No. While patients lose weight while taking a GLP-1 agonist in a dose-dependent and duration-dependent fashion, they will tend to regain weight if the medication is stopped (SOR: A, multiple randomized controlled trials).

How did Kelly Clarkson lose weight? ›

Kelly said she changed her diet.

Kelly shared with People that she's re-vamped her diet, and is focusing on eating lots of protein. “I eat a healthy mix,” she said. “I dropped weight because I've been listening to my doctor—a couple years I didn't.

What is the miracle weight loss drug? ›

Ozempic blew up in 2022 - if media reports from the US were to be believed, every pound dropped in LA was probably thanks to the "miracle" injectable drug. What started as the preserve of A-listers and the Hollywood elite quickly grew in popularity. The drug's generic name is semaglutide.

What BMI is needed for GLP-1? ›

GLP-1 medication research for weight management

In 2014, the FDA approved the first GLP-1 specifically for weight loss for people with a BMI of 30 and above or a BMI of at least 27 with one weight-related comorbid disease, which affects more than half the U.S. adult population.

What is the strongest weight loss prescription pill? ›

Based on data reported in clinical studies, Qsymia is likely the most effective prescription weight-loss pill. It tends to lead to the largest amount of weight loss in the highest percentage of people.

How to increase GLP-1 naturally? ›

Eating more fiber, lean protein, healthy fat, and water-rich fruits and vegetables can increase GLP-1 naturally and help with weight loss. Some small studies show that certain supplements — like berberine, curcumin, and ginseng — boost GLP-1 levels.

Is Wegovy better than Ozempic? ›

Wegovy offers a slightly higher maximum dose of semaglutide than Ozempic. Patients on the former may reach a maintenance dose of 2.4 mg, while Ozempic's maximum dose is 2 mg. This higher available dose of semaglutide gives Wegovy a slight advantage over Ozempic when considering its effectiveness.

What is the cheapest way to get GLP-1? ›

If you have a valid prescription and commercial or private insurance, you may be eligible for a GLP-1 savings offer from the manufacturer. For example, Novo Nordisk, the manufacturer of Ozempic, Wegovy, and Saxenda, offers savings coupons for Wegovy and Ozempic. These can bring down the monthly cost to as low as $25.

Is GLP-1 covered by insurance? ›

The complex nature of these weight-loss drugs makes them a challenging issue when it comes to insurance coverage. According to the International Foundation of Employee Benefit Plans, only 25% of employers provided coverage for GLP-1 drugs for weight loss in 2023.

Which GLP-1 causes the most weight loss? ›

Tirzepatide is the most effective currently available GLP-1 receptor agonist for both glycemic control and weight loss in the short and intermediate term; long-term efficacy and safety are still open questions.

How long to stay on GLP-1 for weight loss? ›

Even though weight loss reaches a plateau after about a year or so, people who take a GLP-1 RA for weight loss might still prefer to stay on it for the long term. This is because, after stopping the medication, it's common for people to regain part of the weight that they lost while they were taking it.

How to keep weight off after stopping Mounjaro? ›

Improve the quality of your diet: Eating a diet based on whole foods and minimising the consumption of ultra-processed foods will help your body regulate your appetite naturally. Exercise: Research has shown that people who exercise more after weight loss are more likely to avoid weight regain in the long term.

Can many patients maintain weight loss a year after stopping semaglutide and liraglutide? ›

Overall, 56.2% patients who took semaglutide maintained their weight 1 year after discontinuing its use. Health care providers should discuss the possibility of weight regain with patients, a researcher said.

What happens when you stop and restart Mounjaro? ›

Mounjaro mimics the hormone glucagon to increase insulin secretion and decrease glucagon production, which can help lower blood sugar levels for people with Type 2 diabetes. Stopping the medication can cause your blood sugar levels to return to what they were before you started taking the medication.

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